This one is simply an exercise in layers of irony. The age-old scenario of "Not tonight dear, I have a headache" played out by ibuprofen (a.k.a. neurofen, right) and aspirin (left). Obviously, a good dose of ibuprofen is not on the cards tonight.
Now that ChemScrapes is finally getting some attention, peer review has started to creep in. In the old days, I never got feedback on the cartoons because they simply didn't get seen. As a result, mistakes used to creep in. Recently on Twitter and separately on Instagram, two people independently pointed out that the structure of aspirin was incorrect in the cartoon. Both quipped "no wonder she has a headache". The corrected version appears below.