Please Explain

Obviously a lot of what goes on ChemScrapes is for a limited audience. Below is a cartoon that was drawn for universal appeal..."Not tonight dear, I have a headache." But who gets it? I am not even sure all chemists would get it.

- Not tonight dear, I have a terrible headache!

On the left is O-acetyl salicylic acid (aspirin). On the right is ibuprofen...........the drug that every parent knows about when the paracetamol doesn't do the job. It is at least ironic, if not funny.